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The redshifted 21 cm signal from the Epoch of Reionization (EoR) directly probes the ionization and thermal states of the intergalactic medium during that period. In particular, the distribution of the ionized regions around the radiating sources during EoR introduces scale-dependent features in the spherically averaged EoR 21 cm signal power spectrum. Aims. The goal is to study these scale-dependent features at different stages of reionization using numerical simulations and to build a source model-independent framework to probe the properties of the intergalactic medium using EoR 21 cm signal power spectrum measurements. Methods. Under the assumption of high spin temperature, we modeled the redshift evolution of the ratio of the EoR 21 cm brightness temperature power spectrum to the corresponding density power spectrum using an ansatz consisting of a set of redshift and scale-independent parameters. This set of eight parameters probes the redshift evolution of the average ionization fraction and the quantities related to the morphology of the ionized regions. Results. We tested this ansatz on different reionization scenarios generated using different simulation algorithms and found that it is able to recover the redshift evolution of the average neutral fraction within an absolute deviation ≲0.1. Conclusions. Our framework allows us to interpret 21 cm signal power spectra in terms of parameters related to the state of the IGM. This source model-independent framework is able to efficiently constrain reionization scenarios using multi-redshift power spectrum measurements with ongoing and future radio telescopes such as LOFAR, MWA, HERA, and SKA. This will add independent information regarding the EoR IGM properties.